Philosophy: Plants being sessile, cannot escape their environmental surroundings, including symbionts, abiotic or biotic sensors. Thus, to adapt and survive, they must regulate gene expression robustly. One of the faster way to achieve that is through post-transcriptional gene regulation, particularly mRNA stability, storage, translation and decay. It allows a finer-tuned “volume-knob” than rewriting genes from the scratch. Though transcription decides what genes get read; post-transcriptional regulation decides how much, when and whether that message becomes a protein, which gives plants a fast and flexible way to cope with a changing world.
RNA regulation acts as a critical interface between a cell’s environment and its capacity to make decisions. To execute precise developmental transitions and respond effectively to stress, cells orchestrate RNA stabilization, translational repression, and decay with tight spatial and temporal control. My current research uses Arabidopsis as a model system to investigate these processes, with the broader aim of extending this framework across diverse biological contexts. I seek to uncover the spatial logic that governs RNA regulatory pathways, and to understand how cellular environments shape RNA fate during the most critical stages of an organism’s development, inn adaptation and in immunity.
Outside the lab, I enjoy writing as a way to reflect on science, ideas, and everyday experiences. I enjoy sharing thoughtful pieces through which I explore the intersection of science, curiosity, and personal experience. I occasionally write book reviews, using reading as another way to think and learn. In addition, I am involved in outreach and community-oriented initiatives, contributing to science communication and education beyond academia. I try to balance my research with these creative pursuits, which give me space to explore curiosity in a different way.
Work experience and Education
Senior Researcher and PostDoctoral Scientist (Aug 2017 – present)
PI: Dr. Karel Riha, CEITEC-MU, Czech Republic
Projects description: Using Arabidopsis thaliana as a model system, I combine molecular biology, genetics, NGS-based approaches, to characterize regulatory networks that coordinate stress adaptation and developmental progression and transitions at the systems level. Also, using Ostreococcus tauri as a minimal eukaryotic cell model to understand the most basic requirements for cellular life. By integrating metabolic labeling, single-cell RNA-seq, polysome profiling and proteomics, we map the intricate processes of this tiny cell to uncover the essential blueprints of division and survival.
The research on “Post-transcriptional gene regulation during anther development in Arabidopsis thaliana” is focussed on how the cell spatially and temporally coordinates RNA stabilization, post-transcriptional regulation, translational repression, and decay to ensure proper developmental transitions. The life cycle of an RNA molecule, governed by sequestration within multi-phase biomolecular condensates and subsequent enzymatic clearance, serves as a primary regulatory hub for maintaining meiotic integrity and ensuring a successful transition to gametophytic mitosis.
Graduate student (Feb 2013 – Feb 2017)
Supervisor: Prof. Amar Kumar, Department of Botany, University of Delhi, India
Thesis title: Transcriptome analysis of root-knot nematode (Meloidogyne incognita)-infected tomato (Solanum lycopersicum) roots reveals complex gene expression profiles and metabolic networks of both plant and nematode during susceptible and resistance responses.
Research fellow (April 2015 – Aug 2015)
Supervisor: Dr. Ramneek Gupta, CBS-DTU, Denmark
Project title: Understanding plant-nematode interaction through identification of plant and nematode genes involved in disease development.
Teaching assistant (2015 – 2016)
Co-taught the course with Prof. Arun Jagannath, Department of Botany, University of Delhi, India (M.Sc. Botany; 1 semester)
Course title: BOT306 – Bioinformatics, Computational Biology and Biostatistics
Masters in Science (Honors) Botany (2010 – 2012)
Specialization: Botany
Dissertation title: Biosensors – A thorough review of literature (Advisor: Prof. Arun Jagannath, Department of Botany, University of Delhi, India)
